Deletion of MGF505-2R Gene Activates the cGAS-STING Pathway Leading to Attenuation and Protection against Virulent African Swine Fever Virus

Deletion of MGF505-2R Gene Activates the cGAS-STING Pathway Leading to Attenuation and Protection against Virulent African Swine Fever Virus

African swine fever virus (ASFV) is the etiological agent causing African swine fever (ASF), affecting domestic pigs and wild boar, which is currently the biggest animal epidemic in the world and a major threat to the swine sector. At present, some safety concerns about using LAVs against ASFV still...

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Bibliographic Details
Main Authors: Sun-Young Sunwoo, Raquel García-Belmonte, Marek Walczak, Gonzalo Vigara-Astillero, Dae-Min Kim, Krzesimir Szymankiewicz, Maciej Kochanowski, Lihong Liu, Dongseob Tark, Katarzyna Podgórska, Yolanda Revilla, Daniel Pérez-Núñez
Format: Article
Language:English
Published: MDPI AG 2024-04-01
Series:Vaccines
Subjects:
ASFV
Arm/07/CBM/c2
MGF505-2R
cGAS-STING
IFN-β
LAV
Online Access:https://www.mdpi.com/2076-393X/12/4/407

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https://www.mdpi.com/2076-393X/12/4/407

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