The Fusion Loops of the Initial Prefusion Conformation of Herpes Simplex Virus 1 Fusion Protein Point Toward the Membrane

ABSTRACT All enveloped viruses, including herpesviruses, must fuse their envelope with the host membrane to deliver their genomes into target cells, making this essential step subject to interference by antibodies and drugs. Viral fusion is mediated by a viral surface protein that transits from an i...

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Bibliographic Details
Main Authors: Juan Fontana, Doina Atanasiu, Wan Ting Saw, John R. Gallagher, Reagan G. Cox, J. Charles Whitbeck, Lauren M. Brown, Roselyn J. Eisenberg, Gary H. Cohen
Format: Article
Language:English
Published: American Society for Microbiology 2017-09-01
Series:mBio
Subjects:
Online Access:https://journals.asm.org/doi/10.1128/mBio.01268-17