Factor H binds to the hypervariable region of many Streptococcus pyogenes M proteins but does not promote phagocytosis resistance or acute virulence.

Many pathogens express a surface protein that binds the human complement regulator factor H (FH), as first described for Streptococcus pyogenes and the antiphagocytic M6 protein. It is commonly assumed that FH recruited to an M protein enhances virulence by protecting the bacteria against complement...

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Bibliographic Details
Main Authors: Mattias C U Gustafsson, Jonas Lannergård, O Rickard Nilsson, Bodil M Kristensen, John E Olsen, Claire L Harris, Rafael L Ufret-Vincenty, Margaretha Stålhammar-Carlemalm, Gunnar Lindahl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3630203?pdf=render