Interaction between TNF and BmooMP-Alpha-I, a Zinc Metalloprotease Derived from Bothrops moojeni Snake Venom, Promotes Direct Proteolysis of This Cytokine: Molecular Modeling and Docking at a Glance

Interaction between TNF and BmooMP-Alpha-I, a Zinc Metalloprotease Derived from Bothrops moojeni Snake Venom, Promotes Direct Proteolysis of This Cytokine: Molecular Modeling and Docking at a Glance

Tumor necrosis factor (TNF) is a major cytokine in inflammatory processes and its deregulation plays a pivotal role in several diseases. Here, we report that a zinc metalloprotease extracted from Bothrops moojeni venom (BmooMP-alpha-I) inhibits TNF directly by promoting its degradation. This inhibit...

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Bibliographic Details
Main Authors: Maraisa Cristina Silva, Tamires Lopes Silva, Murilo Vieira Silva, Caroline Martins Mota, Fernanda Maria Santiago, Kelly Cortes Fonseca, Fábio Oliveira, Tiago Wilson Patriarca Mineo, José Roberto Mineo
Format: Article
Language:English
Published: MDPI AG 2016-07-01
Series:Toxins
Subjects:
BmooMP-alpha-I
zinc metalloprotease
TNF
TACE
Online Access:http://www.mdpi.com/2072-6651/8/7/223

Internet

http://www.mdpi.com/2072-6651/8/7/223

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