Involvement of Epithelial–Mesenchymal Transition Genes in Small Cell Lung Cancer Phenotypic Plasticity

Involvement of Epithelial–Mesenchymal Transition Genes in Small Cell Lung Cancer Phenotypic Plasticity

Small cell lung cancer (SCLC) is an aggressive cancer recalcitrant to treatment, arising predominantly from epithelial pulmonary neuroendocrine (NE) cells. Intratumor heterogeneity plays critical roles in SCLC disease progression, metastasis, and treatment resistance. At least five transcriptional S...

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Bibliographic Details
Main Authors: Sarah M. Groves, Nicholas Panchy, Darren R. Tyson, Leonard A. Harris, Vito Quaranta, Tian Hong
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cancers
Subjects:
small cell lung cancer
epithelial–mesenchymal transition
cellular plasticity
single-cell RNA-sequencing
Online Access:https://www.mdpi.com/2072-6694/15/5/1477

Internet

https://www.mdpi.com/2072-6694/15/5/1477

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