Optogenetic actuator – ERK biosensor circuits identify MAPK network nodes that shape ERK dynamics

Optogenetic actuator – ERK biosensor circuits identify MAPK network nodes that shape ERK dynamics

Abstract Combining single‐cell measurements of ERK activity dynamics with perturbations provides insights into the MAPK network topology. We built circuits consisting of an optogenetic actuator to activate MAPK signaling and an ERK biosensor to measure single‐cell ERK dynamics. This allowed us to co...

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Bibliographic Details
Main Authors: Coralie Dessauges, Jan Mikelson, Maciej Dobrzyński, Marc‐Antoine Jacques, Agne Frismantiene, Paolo Armando Gagliardi, Mustafa Khammash, Olivier Pertz
Format: Article
Language:English
Published: Springer Nature 2022-06-01
Series:Molecular Systems Biology
Subjects:
ERK dynamics
MAPK network
optogenetics
signaling robustness
single‐cell biology
Online Access:https://doi.org/10.15252/msb.202110670

Internet

https://doi.org/10.15252/msb.202110670

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