Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double-blind, randomised, controlled, phase 3 trial

Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double-blind, randomised, controlled, phase 3 trial

Summary: Background: BCG vaccination prevents severe childhood tuberculosis (TB) and was introduced in South Africa in the 1950s. It is hypothesised that BCG trains the innate immune system by inducing epigenetic and functional reprogramming, thus providing non-specific protection from respiratory...

Full description

Bibliographic Details
Main Authors: Caryn M. Upton, Rob C. van Wijk, Laurynas Mockeliunas, Ulrika S.H. Simonsson, Kirsten McHarry, Gerben van den Hoogen, Chantal Muller, Arne von Delft, Helene-Mari van der Westhuizen, Reinout van Crevel, Gerhard Walzl, Pedro M. Baptista, Jonathan Peter, Andreas H. Diacon
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:EClinicalMedicine
Subjects:
COVID-19
BCG
Respiratory tract infection
Vaccine
Tuberculosis
Trained immunity
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537022001444

Internet

http://www.sciencedirect.com/science/article/pii/S2589537022001444

Similar Items