MAB21L1 modulates gene expression and DNA metabolic processes in the lens placode

MAB21L1 modulates gene expression and DNA metabolic processes in the lens placode

Mutations in human MAB21L1 cause aberrations in lens ectoderm morphogenesis and lead to congenital cerebellar, ocular, craniofacial and genital (COFG) syndrome. Murine Mab21l1-null mutations cause severe cell-autonomous defects in lens formation, leading to microphthalmia; therefore, Mab21l1-null mi...

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Bibliographic Details
Main Authors: Ryuichi Yamada, Akira Oguri, Katsunori Fujiki, Katsuhiko Shirahige, Yoshikazu Hirate, Masami Kanai-Azuma, Hirotaka Takezoe, Yoshihiro Akimoto, Naoki Takahashi, Yoshiakira Kanai
Format: Article
Language:English
Published: The Company of Biologists 2021-12-01
Series:Disease Models & Mechanisms
Subjects:
mab21l1
lens placode
scrna-seq
transmission electron microscopy
Online Access:http://dmm.biologists.org/content/14/12/dmm049251

Internet

http://dmm.biologists.org/content/14/12/dmm049251

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