Monoclonal antibodies from humans with Mycobacterium tuberculosis exposure or latent infection recognize distinct arabinomannan epitopes
Elise Ishida et al. generate human monoclonal antibodies that can selectively recognize specific oligosaccharide epitopes of the polysaccharides arabinomannan and lipoarabinomannan, which are critical for M. tuberculosis pathogenesis. The authors demonstrate the utility of these antibodies in both d...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-10-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02714-w |
| _version_ | 1829499716584341504 |
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| author | Elise Ishida Devin T. Corrigan Ryan J. Malonis Daniel Hofmann Tingting Chen Anita G. Amin Delphi Chatterjee Maju Joe Todd L. Lowary Jonathan R. Lai Jacqueline M. Achkar |
| author_facet | Elise Ishida Devin T. Corrigan Ryan J. Malonis Daniel Hofmann Tingting Chen Anita G. Amin Delphi Chatterjee Maju Joe Todd L. Lowary Jonathan R. Lai Jacqueline M. Achkar |
| author_sort | Elise Ishida |
| collection | DOAJ |
| description | Elise Ishida et al. generate human monoclonal antibodies that can selectively recognize specific oligosaccharide epitopes of the polysaccharides arabinomannan and lipoarabinomannan, which are critical for M. tuberculosis pathogenesis. The authors demonstrate the utility of these antibodies in both diagnostic and laboratory settings, making them important tools for M. tuberculosis research. |
| first_indexed | 2024-12-16T08:40:36Z |
| format | Article |
| id | doaj.art-beed135280764d7ba72204f728213be0 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-16T08:40:36Z |
| publishDate | 2021-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-beed135280764d7ba72204f728213be02022-12-21T22:37:41ZengNature PortfolioCommunications Biology2399-36422021-10-014111310.1038/s42003-021-02714-wMonoclonal antibodies from humans with Mycobacterium tuberculosis exposure or latent infection recognize distinct arabinomannan epitopesElise Ishida0Devin T. Corrigan1Ryan J. Malonis2Daniel Hofmann3Tingting Chen4Anita G. Amin5Delphi Chatterjee6Maju Joe7Todd L. Lowary8Jonathan R. Lai9Jacqueline M. Achkar10Department of Microbiology and Immunology, Albert Einstein College of MedicineDepartment of Medicine, Albert Einstein College of MedicineDepartment of Biochemistry, Albert Einstein College of MedicineDepartment of Biochemistry, Albert Einstein College of MedicineDepartment of Medicine, Albert Einstein College of MedicineMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State UniversityMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State UniversityDepartment of Chemistry, University of AlbertaDepartment of Chemistry, University of AlbertaDepartment of Biochemistry, Albert Einstein College of MedicineDepartment of Microbiology and Immunology, Albert Einstein College of MedicineElise Ishida et al. generate human monoclonal antibodies that can selectively recognize specific oligosaccharide epitopes of the polysaccharides arabinomannan and lipoarabinomannan, which are critical for M. tuberculosis pathogenesis. The authors demonstrate the utility of these antibodies in both diagnostic and laboratory settings, making them important tools for M. tuberculosis research.https://doi.org/10.1038/s42003-021-02714-w |
| spellingShingle | Elise Ishida Devin T. Corrigan Ryan J. Malonis Daniel Hofmann Tingting Chen Anita G. Amin Delphi Chatterjee Maju Joe Todd L. Lowary Jonathan R. Lai Jacqueline M. Achkar Monoclonal antibodies from humans with Mycobacterium tuberculosis exposure or latent infection recognize distinct arabinomannan epitopes Communications Biology |
| title | Monoclonal antibodies from humans with Mycobacterium tuberculosis exposure or latent infection recognize distinct arabinomannan epitopes |
| title_full | Monoclonal antibodies from humans with Mycobacterium tuberculosis exposure or latent infection recognize distinct arabinomannan epitopes |
| title_fullStr | Monoclonal antibodies from humans with Mycobacterium tuberculosis exposure or latent infection recognize distinct arabinomannan epitopes |
| title_full_unstemmed | Monoclonal antibodies from humans with Mycobacterium tuberculosis exposure or latent infection recognize distinct arabinomannan epitopes |
| title_short | Monoclonal antibodies from humans with Mycobacterium tuberculosis exposure or latent infection recognize distinct arabinomannan epitopes |
| title_sort | monoclonal antibodies from humans with mycobacterium tuberculosis exposure or latent infection recognize distinct arabinomannan epitopes |
| url | https://doi.org/10.1038/s42003-021-02714-w |
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