Opacification Domain of Serum Opacity Factor Inhibits Beta-Hemolysis and Contributes to Virulence of <named-content content-type="genus-species">Streptococcus pyogenes</named-content>

Opacification Domain of Serum Opacity Factor Inhibits Beta-Hemolysis and Contributes to Virulence of <named-content content-type="genus-species">Streptococcus pyogenes</named-content>

ABSTRACT Serum opacity factor (SOF) is a cell surface virulence factor made by the human pathogen Streptococcus pyogenes. We found that S. pyogenes strains with naturally occurring truncation mutations in the sof gene have markedly enhanced beta-hemolysis. Moreover, deletion of the sof gene in a SOF...

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Bibliographic Details
Main Authors: Luchang Zhu, Randall J. Olsen, James M. Musser
Format: Article
Language:English
Published: American Society for Microbiology 2017-04-01
Series:mSphere
Subjects:
beta-hemolysis
Streptococcus pyogenes
high-density lipoprotein
serum opacity factor
virulence
Online Access:https://journals.asm.org/doi/10.1128/mSphereDirect.00147-17

Internet

https://journals.asm.org/doi/10.1128/mSphereDirect.00147-17

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