Domain organization, catalysis and regulation of eukaryotic cystathionine beta-synthases.

Cystathionine beta-synthase (CBS) is a key regulator of sulfur amino acid metabolism diverting homocysteine, a toxic intermediate of the methionine cycle, via the transsulfuration pathway to the biosynthesis of cysteine. Although the pathway itself is well conserved among eukaryotes, properties of e...

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Bibliographic Details
Main Authors: Tomas Majtan, Angel L Pey, Roberto Fernández, José A Fernández, Luis A Martínez-Cruz, Jan P Kraus
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4133348?pdf=render