FDX1 downregulation activates mitophagy and the PI3K/AKT signaling pathway to promote hepatocellular carcinoma progression by inducing ROS production

FDX1 downregulation activates mitophagy and the PI3K/AKT signaling pathway to promote hepatocellular carcinoma progression by inducing ROS production

Background: Mitochondrial dysfunction and metabolic reprogramming can lead to the development and progression of hepatocellular carcinoma (HCC). Ferredoxin 1 (FDX1) is a small mitochondrial protein and recent studies have shown that FDX1 plays an important role in tumor cuproptosis, but its role in...

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Bibliographic Details
Main Authors: Bo Sun, Peng Ding, Yinghui Song, Jia Zhou, Xu Chen, Chuang Peng, Sulai Liu
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Redox Biology
Subjects:
Hepatocellular carcinoma
Ferredoxin 1
Mitophagy
Reactive oxygen species
PI3K/AKT signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724002805

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http://www.sciencedirect.com/science/article/pii/S2213231724002805

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