Crystal Structure of a Chimeric Antigen Receptor (CAR) scFv Domain Rearrangement Forming a VL-VL Dimer

Crystal Structure of a Chimeric Antigen Receptor (CAR) scFv Domain Rearrangement Forming a VL-VL Dimer

Chimeric Antigen Receptor T-cell (CAR-T) immunotherapies are dependent upon designed transmembrane proteins to bind target antigens and stimulate an immune response. The success or failure of these CARs is only partially predictable, yet recent work has highlighted the importance of antigen binding...

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Bibliographic Details
Main Authors: Jonah Cheung, Shagun Wazir, David R. Bell, James N. Kochenderfer, Wayne A. Hendrickson, Philippe Youkharibache
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Crystals
Subjects:
CAR-T cell
immunotherapy
chimeric antigen receptor
VH-VL interface
Ig domains
Online Access:https://www.mdpi.com/2073-4352/13/4/710

Internet

https://www.mdpi.com/2073-4352/13/4/710

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