The inhibitory effect of boric acid on hypoxia-regulated tumour-associated carbonic anhydrase IX

The inhibitory effect of boric acid on hypoxia-regulated tumour-associated carbonic anhydrase IX

Carbonic anhydrases (EC 4.2.1.1) catalyse the reversible hydration of CO2 into bicarbonate and protons. As a hypoxia-sensitive and tumour-associated isoform, isoform CA IX, is significantly overexpressed in various malignancies, being a validated target for new anticancer/antimetastatic drugs. A mul...

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Bibliographic Details
Main Authors: Zainab Saad Yusuf, Tugba Kevser Uysal, Ender Simsek, Alessio Nocentini, Sameh Mohamed Osman, Claudiu T. Supuran, Özen Özensoy Güler
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Boric acid
carbonic anhydrase
isoform CA IX
enzyme inhibitor
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2022.2072837

Internet

https://www.tandfonline.com/doi/10.1080/14756366.2022.2072837

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