Thalidomide is more efficient than sodium butyrate in enhancing GATA-1 and EKLF gene expression in erythroid progenitors derived from HSCs with β-globin gene mutation

Thalidomide is more efficient than sodium butyrate in enhancing GATA-1 and EKLF gene expression in erythroid progenitors derived from HSCs with β-globin gene mutation

Background: Efficient induction of fetal hemoglobin (HbF) is considered as an effective therapeutic approach in beta thalassemia. HbF inducer agents can induce the expression of γ-globin gene and produce high levels of HbF via different epigenetic and molecular mechanisms. Thalidomide and sodium but...

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Bibliographic Details
Main Authors: Mohammad Ali Jalali Far, Ali Dehghani Fard, Saiedeh Hajizamani, Majid Mossahebi-Mohammadi, Hamid Yaghooti, Najmaldin Saki
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2016-04-01
Series:International Journal of Hematology-Oncology and Stem Cell Research
Subjects:
Fetal hemoglobin
Thalidomide
Sodium butyrate
β-thalassemia
Online Access:https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/368

Internet

https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/368

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