Studying the Roles of the Renin–Angiotensin System in Accelerating the Disease of High-Fat-Diet-Induced Diabetic Nephropathy in a db/db and ACE2 Double-Gene-Knockout Mouse Model

Studying the Roles of the Renin–Angiotensin System in Accelerating the Disease of High-Fat-Diet-Induced Diabetic Nephropathy in a db/db and ACE2 Double-Gene-Knockout Mouse Model

Diabetic nephropathy (DN) is a crucial metabolic health problem. The renin–angiotensin system (RAS) is well known to play an important role in DN. Abnormal RAS activity can cause the over-accumulation of angiotensin II (Ang II). Angiotensin-converting enzyme inhibitor (ACEI) administration has been...

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Bibliographic Details
Main Authors: Cheng-Yi Chen, Meng-Wei Lin, Xing-Yang Xie, Cheng-Han Lin, Chung-Wei Yang, Pei-Ching Wu, Dung-Huan Liu, Chih-Jen Wu, Chih-Sheng Lin
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
diabetic nephropathy
renin angiotensin system
high-fat-diet
angiotensin converting enzyme II (ACE2)
chymase
Online Access:https://www.mdpi.com/1422-0067/25/1/329

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https://www.mdpi.com/1422-0067/25/1/329

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