SIRT2 inhibition protects against cardiac hypertrophy and ischemic injury

SIRT2 inhibition protects against cardiac hypertrophy and ischemic injury

Sirtuins (SIRT) exhibit deacetylation or ADP-ribosyltransferase activity and regulate a wide range of cellular processes in the nucleus, mitochondria, and cytoplasm. The role of the only sirtuin that resides in the cytoplasm, SIRT2, in the development of ischemic injury and cardiac hypertrophy is no...

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Bibliographic Details
Main Authors: Xiaoyan Yang, Hsiang-Chun Chang, Yuki Tatekoshi, Amir Mahmoodzadeh, Maryam Balibegloo, Zeinab Najafi, Rongxue Wu, Chunlei Chen, Tatsuya Sato, Jason Shapiro, Hossein Ardehali
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-09-01
Series:eLife
Subjects:
heart failure
sirtuins
cardiac hypertrophy
Online Access:https://elifesciences.org/articles/85571

Internet

https://elifesciences.org/articles/85571

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