RORγt-Raftlin1 complex regulates the pathogenicity of Th17 cells and colonic inflammation

RORγt-Raftlin1 complex regulates the pathogenicity of Th17 cells and colonic inflammation

Abstract Th17 cells that produce Interleukin IL-17 are pathogenic in many human diseases, including inflammatory bowel disease, but are, paradoxically, essential for maintaining the integrity of the intestinal barrier in a non-inflammatory state. However, the intracellular mechanisms that regulate d...

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Bibliographic Details
Main Authors: Amir Kumar Singh, Ritesh Kumar, Jianyi Yin, John F. Brooks II, Mahesh Kathania, Sandip Mukherjee, Jitendra Kumar, Kevin P. Conlon, Venkatesha Basrur, Zhe Chen, Xianlin Han, Lora V. Hooper, Ezra Burstein, K. Venuprasad
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40622-1

Internet

https://doi.org/10.1038/s41467-023-40622-1

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