Isoliquiritigenin Activates Nuclear Factor Erythroid-2 Related Factor 2 to Suppress the NOD-Like Receptor Protein 3 Inflammasome and Inhibits the NF-κB Pathway in Macrophages and in Acute Lung Injury

Isoliquiritigenin Activates Nuclear Factor Erythroid-2 Related Factor 2 to Suppress the NOD-Like Receptor Protein 3 Inflammasome and Inhibits the NF-κB Pathway in Macrophages and in Acute Lung Injury

Among the cellular response mechanisms, the nuclear factor erythroid-2 related factor 2 (Nrf2) pathway is considered a survival pathway that alleviates oxidative injury, while both the NOD-like receptor protein 3 (NLRP3) and NF-κB pathways are pro-inflammatory pathways that cause damage to cells. Th...

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Bibliographic Details
Main Authors: Qinmei Liu, Hongming Lv, Zhongmei Wen, Xinxin Ci, Liping Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
isoliquiritigenin
oxidative stress
inflammation
acute lung injury
AMP-activated protein kinase/nuclear factor erythroid-2 related factor 2
NOD-like receptor protein 3
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01518/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01518/full

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