Plk1 inhibition causes post-mitotic DNA damage and senescence in a range of human tumor cell lines.

Plk1 inhibition causes post-mitotic DNA damage and senescence in a range of human tumor cell lines.

Plk1 is a checkpoint protein whose role spans all of mitosis and includes DNA repair, and is highly conserved in eukaryotes from yeast to man. Consistent with this wide array of functions for Plk1, the cellular consequences of Plk1 disruption are diverse, spanning delays in mitotic entry, mitotic sp...

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Bibliographic Details
Main Authors: Denise L Driscoll, Arijit Chakravarty, Doug Bowman, Vaishali Shinde, Kerri Lasky, Judy Shi, Tricia Vos, Bradley Stringer, Ben Amidon, Natalie D'Amore, Marc L Hyer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4218841?pdf=render

Internet

http://europepmc.org/articles/PMC4218841?pdf=render

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