Development of Transdermal Oleogel Containing Olmesartan Medoxomil: Statistical Optimization and Pharmacological Evaluation

Development of Transdermal Oleogel Containing Olmesartan Medoxomil: Statistical Optimization and Pharmacological Evaluation

Olmesartan medoxomil (OLM) is a first-line antihypertensive drug with low oral bioavailability (28.6%). This study aimed to develop oleogel formulations to decrease OLM side effects and boost its therapeutic efficacy and bioavailability. OLM oleogel formulations were composed of Tween 20, Aerosil 20...

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Bibliographic Details
Main Authors: Rania Moataz El-Dahmy, Ibrahim Elsayed, Jihan Hussein, Mohammad Althubiti, Riyad A. Almaimani, Mahmoud Zaki El-Readi, Marawan A. Elbaset, Bassant M. M. Ibrahim
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Pharmaceutics
Subjects:
oleogel
olmesartan medoxomil
central composite design
texture analysis
ex vivo permeation
pharmacodynamic study
Online Access:https://www.mdpi.com/1999-4923/15/4/1083

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https://www.mdpi.com/1999-4923/15/4/1083

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