Mnk2 Alternative Splicing Modulates the p38-MAPK Pathway and Impacts Ras-Induced Transformation

Mnk2 Alternative Splicing Modulates the p38-MAPK Pathway and Impacts Ras-Induced Transformation

Summary: The kinase Mnk2 is a substrate of the MAPK pathway and phosphorylates the translation initiation factor eIF4E. In humans, MKNK2, the gene encoding for Mnk2, is alternatively spliced yielding two splicing isoforms with differing last exons: Mnk2a, which contains a MAPK-binding domain, and Mn...

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Bibliographic Details
Main Authors: Avraham Maimon, Maxim Mogilevsky, Asaf Shilo, Regina Golan-Gerstl, Akram Obiedat, Vered Ben-Hur, Ilana Lebenthal-Loinger, Ilan Stein, Reuven Reich, Jonah Beenstock, Eldar Zehorai, Claus L. Andersen, Kasper Thorsen, Torben F. Ørntoft, Roger J. Davis, Ben Davidson, David Mu, Rotem Karni
Format: Article
Language:English
Published: Elsevier 2014-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714002381

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http://www.sciencedirect.com/science/article/pii/S2211124714002381

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