Metabolomics Analysis Reveals Altered Metabolic Pathways and Response to Doxorubicin in Drug-Resistant Triple-Negative Breast Cancer Cells

Metabolomics Analysis Reveals Altered Metabolic Pathways and Response to Doxorubicin in Drug-Resistant Triple-Negative Breast Cancer Cells

This study aimed to investigate metabolic changes following the acquisition of resistance to doxorubicin in the triple-negative breast cancer (TNBC) cell line MDA-MB-231. Two drug-resistant cell lines, DOX-RES-50 and DOX-RES-100, were generated by treating MDA-MB-231 cells with doxorubicin for 24 h...

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Bibliographic Details
Main Authors: Blake R. Rushing, Sabrina Molina, Susan Sumner
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Metabolites
Subjects:
metabolomics
triple-negative breast cancer
drug resistance
doxorubicin
chemotherapy
Online Access:https://www.mdpi.com/2218-1989/13/7/865

Internet

https://www.mdpi.com/2218-1989/13/7/865

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