Inhibition of Protein Phosphatase 2A Sensitizes Mucoepidermoid Carcinoma to Chemotherapy via the PI3K-AKT Pathway in Response to Insulin Stimulus

Inhibition of Protein Phosphatase 2A Sensitizes Mucoepidermoid Carcinoma to Chemotherapy via the PI3K-AKT Pathway in Response to Insulin Stimulus

Background/Aims: Protein phosphatase 2A (PP2A) is a ubiquitous serine/threonine phosphatase that mediates cell cycle regulation and metabolism. Mounting evidence has indicated that PP2A inhibition exhibits considerable anticancer potency in multiple types of human cancers. However, the efficacy of P...

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Bibliographic Details
Main Authors: Limin Liu, Herui Wang, Jing Cui, Qi Zhang, Wei Zhang, Wanlin Xu, Hao Lu, Shengwen Liu, Shukun Shen, Francia Fang, Lei Li, Wenjun Yang, Zhengping Zhuang, Jiang Li
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-10-01
Series:Cellular Physiology and Biochemistry
Subjects:
Mucoepidermoid carcinoma
Protein phosphatase 2A
LB100
Chemotherapy
PI3K/AKT pathway
Online Access:https://www.karger.com/Article/FullText/494008

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https://www.karger.com/Article/FullText/494008

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