ZnO nanoparticles attenuate polymer-wear-particle induced inflammatory osteolysis by regulating the MEK-ERK-COX-2 axis

ZnO nanoparticles attenuate polymer-wear-particle induced inflammatory osteolysis by regulating the MEK-ERK-COX-2 axis

Background/Objectives: Advanced thermoplastic materials, such as polyether-ether-ketone (PEEK) and highly cross-linked polyethylene (HXLPE), have been increasingly used as orthopaedic implant materials. Similar to other implants, PEEK-on-HXLPE prostheses produce debris from polymer wear that may act...

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Bibliographic Details
Main Authors: Xiangchao Meng, Wei Zhang, Zhuocheng Lyu, Teng Long, You Wang
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Journal of Orthopaedic Translation
Subjects:
Inflammatory osteolysis
Mitogen-activated protein kinase pathway
Wear particle
Zinc oxide nanoparticles
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X22000298

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http://www.sciencedirect.com/science/article/pii/S2214031X22000298

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