PRMT1 methylation of WTAP promotes multiple myeloma tumorigenesis by activating oxidative phosphorylation via m6A modification of NDUFS6

PRMT1 methylation of WTAP promotes multiple myeloma tumorigenesis by activating oxidative phosphorylation via m6A modification of NDUFS6

Abstract Epigenetic modifications play important roles during the pathogenesis of multiple myeloma (MM). Herein, we found that protein arginine methyltransferase 1 (PRMT1) was highly expressed in MM patients, which was positively correlated with MM stages. High PRMT1 expression was correlated with a...

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Bibliographic Details
Main Authors: Yachun Jia, Xiao Yu, Rui Liu, Luyi Shi, Hua Jin, Dan Yang, Xiaofeng Zhang, Ying Shen, Yuandong Feng, Peihua Zhang, Yi Yang, Linlin Zhang, Pengyu Zhang, Zongfang Li, Aili He, Guangyao Kong
Format: Article
Language:English
Published: Nature Publishing Group 2023-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06036-z

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https://doi.org/10.1038/s41419-023-06036-z

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