NANOPARTICLE-BASED formulation of dihydroartemisinin-lumefantrine duo-drugs: Preclinical Evaluation and enhanced antimalarial efficacy in a mouse model

NANOPARTICLE-BASED formulation of dihydroartemisinin-lumefantrine duo-drugs: Preclinical Evaluation and enhanced antimalarial efficacy in a mouse model

Artemisinin-based combinations (ACTs) are World Health Organization-recommended treatment for malaria. Artemether (A) and lumefantrine (LUM) were the first co-formulated ACT and first-line treatment for malaria globally, artemether is dihydroartemisinin's (DHA's) prodrug. Artemisinins and...

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Bibliographic Details
Main Authors: Pesila Akeyo Odera, Geoffrey Otieno, Joab Otieno Onyango, James Jorum Owuor, Florence Anyango Oloo, Martin Ongas, Jeremiah Gathirwa, Bernhards Ogutu
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Heliyon
Subjects:
Nanoformulation
Malaria
Lumefantrine
dihydroartemisinin
Antimalarials
Toxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024028998

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http://www.sciencedirect.com/science/article/pii/S2405844024028998

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