Correcting a PLC Mutation in the Human Germ Line to Overcome Hereditary Infertility

Correcting a PLC Mutation in the Human Germ Line to Overcome Hereditary Infertility

Human germline gene correction by CRISPR/Cas9 holds great promise to eliminate transmission of genetic mutations. Recent studies have however made troublesome observations of mosaicism (the occurrence of multiple genetic events in one embryo) and loss-of-heterozygosity (LOH, loss of the allele of on...

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Bibliographic Details
Main Authors: Bieke BEKAERT, Annekatrien BOEL, Lisa DE WITTE, Mina POPOVIC, Panagiotis STAMATIADIS, Gwenny COSEMANS, Lise TORDEURS, Susana MARINA CHUVA DE SOUSA LOPES, Petra DE SUTTER, Björn MENTEN, Dominic STOOP, Paul COUCKE, Björn HEINDRYCKX
Format: Article
Language:English
Published: World Scientific Publishing 2022-09-01
Series:Fertility & Reproduction
Online Access:https://www.worldscientific.com/doi/10.1142/S2661318222740012

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https://www.worldscientific.com/doi/10.1142/S2661318222740012

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