Efficacy of IAPP suppression in mouse and human islets by GLP-1 analogue conjugated antisense oligonucleotide

Efficacy of IAPP suppression in mouse and human islets by GLP-1 analogue conjugated antisense oligonucleotide

Insulin resistance is the major risk factor for Type 2 diabetes (T2D). In vulnerable individuals, insulin resistance induces a progressive loss of insulin secretion with islet pathology revealing a partial deficit of beta cells and islet amyloid derived from islet amyloid polypeptide (IAPP). IAPP is...

Full description

Bibliographic Details
Main Authors: Tatyana Gurlo, Thazha P. Prakash, Zhongying Wang, Maani Archang, Lina Pei, Madeline Rosenberger, Elaine Pirie, Richard G. Lee, Peter C. Butler
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Molecular Biosciences
Subjects:
islet amyloid polypeptide (IAPP)
antisense oligonucleotide (ASO)
glucagon-like peptide 1 (GLP-1)
islet
diabetes
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1096286/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1096286/full

Similar Items