Exploring Ligand Binding Domain Dynamics in the NRs Superfamily

Exploring Ligand Binding Domain Dynamics in the NRs Superfamily

Nuclear receptors (NRs) are transcription factors that play an important role in multiple diseases, such as cancer, inflammation, and metabolic disorders. They share a common structural organization composed of five domains, of which the ligand-binding domain (LBD) can adopt different conformations...

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Bibliographic Details
Main Authors: Giulia D’Arrigo, Ida Autiero, Eleonora Gianquinto, Lydia Siragusa, Massimo Baroni, Gabriele Cruciani, Francesca Spyrakis
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
nuclear receptors
flexibility
drug design
agonists
antagonists
ligand binding domain
Online Access:https://www.mdpi.com/1422-0067/23/15/8732

Internet

https://www.mdpi.com/1422-0067/23/15/8732

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