Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis

Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis

Abstract The beta‑site amyloid precursor protein (APP) cleaving enzyme (BACE1) was discovered due to its “amyloidogenic” activity which contributes to the production of amyloid-beta (Aβ) peptides. However, BACE1 also possesses an “amyloidolytic” activity, whereby it degrades longer Aβ peptides into...

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Bibliographic Details
Main Authors: Irem Ulku, Filip Liebsch, S. Can Akerman, Jana F. Schulz, Luka Kulic, Christoph Hock, Claus Pietrzik, Alessandro Di Spiezio, Gopal Thinakaran, Paul Saftig, Gerhard Multhaup
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-28846-z

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https://doi.org/10.1038/s41598-023-28846-z

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