Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis
Abstract The beta‑site amyloid precursor protein (APP) cleaving enzyme (BACE1) was discovered due to its “amyloidogenic” activity which contributes to the production of amyloid-beta (Aβ) peptides. However, BACE1 also possesses an “amyloidolytic” activity, whereby it degrades longer Aβ peptides into...
| Main Authors: | , , , , , , , , , , |
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| 格式: | 文件 |
| 语言: | English |
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Nature Portfolio
2023-02-01
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| 丛编: | Scientific Reports |
| 在线阅读: | https://doi.org/10.1038/s41598-023-28846-z |