Inhibition of dengue virus replication by novel inhibitors of RNA-dependent RNA polymerase and protease activities

Inhibition of dengue virus replication by novel inhibitors of RNA-dependent RNA polymerase and protease activities

Dengue virus (DENV) is the leading mosquito-transmitted viral infection in the world. With more than 390 million new infections annually, and up to 1 million clinical cases with severe disease manifestations, there continues to be a need to develop new antiviral agents against dengue infection. In a...

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Bibliographic Details
Main Authors: Sveva Pelliccia, Yu-Hsuan Wu, Antonio Coluccia, Giuseppe La Regina, Chin-Kai Tseng, Valeria Famiglini, Domiziana Masci, John Hiscott, Jin-Ching Lee, Romano Silvestri
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
DENV inhibitors
RdRp
NS3 protease
ICR-suckling mouse
synergy
Online Access:http://dx.doi.org/10.1080/14756366.2017.1355791

Internet

http://dx.doi.org/10.1080/14756366.2017.1355791

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