Single-cell RNA sequencing uncovers heterogenous immune cell responses upon exposure to food additive (E171) titanium dioxide

Single-cell RNA sequencing uncovers heterogenous immune cell responses upon exposure to food additive (E171) titanium dioxide

Abstract The prospective use of food additive titanium dioxide (E171 TiO2) in a variety of fields (food, pharmaceutics, and cosmetics) prompts proper cellular cytotoxicity and transcriptomic assessment. Interestingly, smaller-sized E171 TiO2 can translocate in bloodstream and induce a diverse immuno...

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Bibliographic Details
Main Authors: Haribalan Perumalsamy, Xiao Xiao, Hyoung-Yun Han, Jung-Hwa Oh, Seokjoo Yoon, Min Beom Heo, Tae Geol Lee, Hyun-Yi Kim, Tae-Hyun Yoon
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Nanobiotechnology
Subjects:
E171 TiO2
scRNAseq analysis
Rat peripheral blood mononuclear cells
Immune response
Heterogeneity
Online Access:https://doi.org/10.1186/s12951-024-03036-9

Internet

https://doi.org/10.1186/s12951-024-03036-9

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