Gasdermin‐E‐Dependent Non‐Canonical Pyroptosis Promotes Drug‐Induced Liver Failure by Promoting CPS1 deISGylation and Degradation

Gasdermin‐E‐Dependent Non‐Canonical Pyroptosis Promotes Drug‐Induced Liver Failure by Promoting CPS1 deISGylation and Degradation

Abstract Drug‐induced liver injury (DILI) is a significant global health issue that poses high mortality and morbidity risks. One commonly observed cause of DILI is acetaminophen (APAP) overdose. GSDME is an effector protein that induces non‐canonical pyroptosis. In this study, the activation of GSD...

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Bibliografski detalji
Glavni autori: Shen‐Xi Ouyang, Jia‐Hui Zhu, Qi Cao, Jian Liu, Zhen Zhang, Yan Zhang, Jing‐Wen Wu, Si‐Jia Sun, Jiang‐Tao Fu, Yi‐Ting Chen, Jie Tong, Yi Liu, Jia‐Bao Zhang, Fu‐Ming Shen, Dong‐Jie Li, Pei Wang
Format: Članak
Jezik:English
Izdano: Wiley 2024-04-01
Serija:Advanced Science
Teme:
ammonia metabolism
CPS1
gasdermin
ISG15
ISGylation
liver injury
Online pristup:https://doi.org/10.1002/advs.202305715

Internet

https://doi.org/10.1002/advs.202305715

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