Novel Sterically Crowded and Conformationally Constrained α-Aminophosphonates with a Near-Neutral p<i>K<sub>a</sub></i> as Highly Accurate <sup>31</sup>P NMR pH Probes. Application to Subtle pH Gradients Determination in <i>Dictyostelium discoideum</i> Cells

Novel Sterically Crowded and Conformationally Constrained α-Aminophosphonates with a Near-Neutral p<i>K<sub>a</sub></i> as Highly Accurate <sup>31</sup>P NMR pH Probes. Application to Subtle pH Gradients Determination in <i>Dictyostelium discoideum</i> Cells

In order to discover new <sup>31</sup>P NMR markers for probing subtle pH changes (<0.2 pH unit) in biological environments, fifteen new conformationally constrained or sterically hindered α-aminophosphonates derived from diethyl(2-methylpyrrolidin-2-yl)phosphonate were synthesized an...

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Bibliografiske detaljer
Main Authors: Caroline Delehedde, Marcel Culcasi, Emilie Ricquebourg, Mathieu Cassien, Didier Siri, Bruno Blaive, Sylvia Pietri, Sophie Thétiot-Laurent
Format: Article
Sprog:English
Udgivet: MDPI AG 2022-07-01
Serier:Molecules
Fag:
α-aminophosphonates
pH probes
<sup>31</sup>P NMR
phophorus pyramidalization angle
X-ray crystallography
trans-sarcolemmal pH gradients
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