Preparation and Cytotoxic Evaluation of PGV-1 Derivative, CCA-1.1, as a New Curcumin Analog with Improved-Physicochemical and Pharmacological Properties

Preparation and Cytotoxic Evaluation of PGV-1 Derivative, CCA-1.1, as a New Curcumin Analog with Improved-Physicochemical and Pharmacological Properties

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Purpose: This study aimed to challenge the anticancer potency of pentagamavunone-1 (PGV-1) and obtain a new compound (Chemoprevention-Curcumin Analog 1.1, CCA-1.1) withimproved chemical and pharmacological properties.Methods: CCA-1.1 was prepared by changing the ketone group of PGV-1 into a hydroxyl...

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Bibliographic Details
Main Authors: Rohmad Yudi Utomo, Febri Wulandari, Dhania Novitasari, Beni Lestari, Ratna Asmah Susidarti, Riris Istighfari Jenie, Jun-ya Kato, Sardjiman Sardjiman, Edy Meiyanto
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2022-05-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
curcumin analog
cca-1.1
nf-κb
reactive oxygen species
cytotoxic
Online Access:https://apb.tbzmed.ac.ir/PDF/apb-12-603.pdf

Internet

https://apb.tbzmed.ac.ir/PDF/apb-12-603.pdf

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