β-Adrenergic Stimulation Synchronizes a Broad Spectrum of Action Potential Firing Rates of Cardiac Pacemaker Cells toward a Higher Population Average

β-Adrenergic Stimulation Synchronizes a Broad Spectrum of Action Potential Firing Rates of Cardiac Pacemaker Cells toward a Higher Population Average

The heartbeat is initiated by pacemaker cells residing in the sinoatrial node (SAN). SAN cells generate spontaneous action potentials (APs), i.e., normal automaticity. The sympathetic nervous system increases the heart rate commensurate with the cardiac output demand via stimulation of SAN β-adrener...

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Bibliographic Details
Main Authors: Mary S. Kim, Oliver Monfredi, Larissa A. Maltseva, Edward G. Lakatta, Victor A. Maltsev
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
heart rate
automaticity
pacemaker
sinoatrial node cell
β-adrenergic receptors
fight-or-flight response
Online Access:https://www.mdpi.com/2073-4409/10/8/2124

Internet

https://www.mdpi.com/2073-4409/10/8/2124

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