Dissecting the Arginine and Lysine Biosynthetic Pathways and Their Relationship in Haloarchaeon Natrinema gari J7-2 via Endogenous CRISPR-Cas System-Based Genome Editing

Dissecting the Arginine and Lysine Biosynthetic Pathways and Their Relationship in Haloarchaeon Natrinema gari J7-2 via Endogenous CRISPR-Cas System-Based Genome Editing

ABSTRACT The evolutionary relationship between arginine and lysine biosynthetic pathways has been well established in bacteria and hyperthermophilic archaea but remains largely unknown in haloarchaea. Here, the endogenous CRISPR-Cas system was harnessed to edit arginine and lysine biosynthesis-relat...

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Bibliographic Details
Main Authors: Yi Wu, Jia Zhang, Bingxue Wang, Yanyan Zhang, Huai Li, Yang Liu, Jing Yin, Dan He, Hongyi Luo, Fei Gan, Bing Tang, Xiao-Feng Tang
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:Microbiology Spectrum
Subjects:
haloarchaea
CRISPR
genome editing
arginine biosynthesis
lysine biosynthesis
diaminopimelate pathway
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00288-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.00288-23

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