HSP90 is part of a protein complex with the L polymerase of Rift Valley fever phlebovirus and prevents its degradation by the proteasome during the viral genome replication/transcription stage

HSP90 is part of a protein complex with the L polymerase of Rift Valley fever phlebovirus and prevents its degradation by the proteasome during the viral genome replication/transcription stage

The mosquito-borne Rift Valley fever virus (RVFV) from the Phenuiviridae family is a single-stranded RNA virus that causes the re-emerging zoonotic disease Rift Valley fever (RVF). Classified as a Category A agent by the NIH, RVFV infection can cause debilitating disease or death in humans and lead...

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Bibliographic Details
Main Authors: Farhang Alem, Ashwini Brahms, Kaori Tarasaki, Samson Omole, Kylene Kehn-Hall, Connie S. Schmaljohn, Sina Bavari, Shinji Makino, Ramin M. Hakami
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Rift Valley fever virus
RNA-dependent RNA polymerase
L protein
Hsp90
heat shock protein
protein stability
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2024.1331755/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2024.1331755/full

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