Integrative multi-omics analysis unveils stemness-associated molecular subtypes in prostate cancer and pan-cancer: prognostic and therapeutic significance

Integrative multi-omics analysis unveils stemness-associated molecular subtypes in prostate cancer and pan-cancer: prognostic and therapeutic significance

Abstract Background Prostate cancer (PCA) is the fifth leading cause of cancer-related deaths worldwide, with limited treatment options in the advanced stages. The immunosuppressive tumor microenvironment (TME) of PCA results in lower sensitivity to immunotherapy. Although molecular subtyping is exp...

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Bibliographic Details
Main Authors: Kun Zheng, Youlong Hai, Yue Xi, Yukun Zhang, Zheqi Liu, Wantao Chen, Xiaoyong Hu, Xin Zou, Jie Hao
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Translational Medicine
Subjects:
Prostate cancer
Stemness subtype
RNA sequencing
Pan‑cancer
Machine learning
Immunotherapy
Online Access:https://doi.org/10.1186/s12967-023-04683-6

Internet

https://doi.org/10.1186/s12967-023-04683-6

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