Ribociclib (LEE011) suppresses cell proliferation and induces apoptosis of MDA-MB-231 by inhibiting CDK4/6-cyclin D-Rb-E2F pathway

Ribociclib (LEE011) suppresses cell proliferation and induces apoptosis of MDA-MB-231 by inhibiting CDK4/6-cyclin D-Rb-E2F pathway

Triple-negative breast cancer (TNBC) stands for a refractory subtype, which predicts poor prognosis and has no effective therapies yet for improving it. Given the restrictions of traditional treatments, novel therapeutic strategies need excavating to alleviate the intrinsic or acquired resistance. R...

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Bibliographic Details
Main Authors: Tianqi Li, Yudi Xiong, Qingqing Wang, Fengxia Chen, Yangyang Zeng, Xiaoyan Yu, Yuan Wang, Fuxiang Zhou, Yunfeng Zhou
Format: Article
Language:English
Published: Taylor & Francis Group 2019-12-01
Series:Artificial Cells, Nanomedicine, and Biotechnology
Subjects:
Triple-negative breast cancer
ribociclib (LEE011)
proliferation
cell cycle
apoptosis
Online Access:https://www.tandfonline.com/doi/10.1080/21691401.2019.1670670

Internet

https://www.tandfonline.com/doi/10.1080/21691401.2019.1670670

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