Formation of Transient Protein Aggregate-like Centers Is a General Strategy Postponing Degradation of Misfolded Intermediates

Formation of Transient Protein Aggregate-like Centers Is a General Strategy Postponing Degradation of Misfolded Intermediates

When misfolded intermediates accumulate during heat shock, the protein quality control system promotes cellular adaptation strategies. In <i>Schizosaccharomyces pombe</i>, thermo-sensitive proteins assemble upon stress into protein aggregate-like centers, PACs, to escape from degradation...

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Bibliographic Details
Main Authors: Susanna Boronat, Margarita Cabrera, Montserrat Vega, Jorge Alcalá, Silvia Salas-Pino, Rafael R. Daga, José Ayté, Elena Hidalgo
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
heat shock response
protein aggregation-like centers
budding yeast
W303 vs. BY4741
fission yeast
Mas5
Online Access:https://www.mdpi.com/1422-0067/24/13/11202

Internet

https://www.mdpi.com/1422-0067/24/13/11202

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