CRNDE mediated hnRNPA2B1 stability facilitates nuclear export and translation of KRAS in colorectal cancer

Abstract Development of colorectal cancer (CRC) involves activation of Kirsten rat sarcoma viral oncogene homolog (KRAS) signaling. However, the post-transcriptional regulation of KRAS has yet to be fully characterized. Here, we found that the colorectal neoplasia differentially expressed (CRNDE)/he...

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Bibliographic Details
Main Authors: Ya Lu, Renrui Zou, Quan Gu, Xinyue Wang, Junying Zhang, Rong Ma, Ting Wang, Jianzhong Wu, Jifeng Feng, Yuan Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2023-09-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06137-9