A Targeted Oligonucleotide Enhancer of SMN2 Exon 7 Splicing Forms Competing Quadruplex and Protein Complexes in Functional Conditions

A Targeted Oligonucleotide Enhancer of SMN2 Exon 7 Splicing Forms Competing Quadruplex and Protein Complexes in Functional Conditions

Summary: The use of oligonucleotides to activate the splicing of selected exons is limited by a poor understanding of the mechanisms affected. A targeted bifunctional oligonucleotide enhancer of splicing (TOES) anneals to SMN2 exon 7 and carries an exonic splicing enhancer (ESE) sequence. We show th...

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Bibliographic Details
Main Authors: Lindsay D. Smith, Rachel L. Dickinson, Christian M. Lucas, Alex Cousins, Alexey A. Malygin, Carika Weldon, Andrew J. Perrett, Andrew R. Bottrill, Mark S. Searle, Glenn A. Burley, Ian C. Eperon
Format: Article
Language:English
Published: Elsevier 2014-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471400727X

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http://www.sciencedirect.com/science/article/pii/S221112471400727X

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