Inhibition of cc chemokine receptor 10 ameliorates osteoarthritis via inhibition of the phosphoinositide-3-kinase/Akt/mammalian target of rapamycin pathway

Inhibition of cc chemokine receptor 10 ameliorates osteoarthritis via inhibition of the phosphoinositide-3-kinase/Akt/mammalian target of rapamycin pathway

Abstract Background Osteoarthritis (OA) is a joint disease characterized by inflammation and progressive cartilage degradation. Chondrocyte apoptosis is the most common pathological feature of OA. Interleukin-1β (IL-1β), a major inflammatory cytokine that promotes cartilage degradation in OA, often...

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Bibliographic Details
Main Authors: Yan Luo, Feng Zhou, Xiaojing Wang, Runwei Yang, Yi Li, Xiaochun Wu, Bin Ye
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
CCR10
Osteoarthritis
PI3K/Akt/mTOR pathway
Online Access:https://doi.org/10.1186/s13018-024-04642-x

Internet

https://doi.org/10.1186/s13018-024-04642-x

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