Optimizing CD8+ T cell-based immunotherapy via metabolic interventions: a comprehensive review of intrinsic and extrinsic modulators

Optimizing CD8+ T cell-based immunotherapy via metabolic interventions: a comprehensive review of intrinsic and extrinsic modulators

Abstract CD8+ T cells are integral to the effective management of cancer and infectious diseases due to their cytotoxic functions. The efficacy of these cells is profoundly influenced by their metabolic state, which regulates their activation, differentiation, and longevity. Accordingly, the modulat...

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Bibliographic Details
Main Authors: Zihao Zhou, Jiarong Zheng, Ye Lu, Zizhao Mai, Yunfan Lin, Pei Lin, Yucheng Zheng, Xu Chen, Rongwei Xu, Xinyuan Zhao, Li Cui
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Experimental Hematology & Oncology
Subjects:
CD8+ T cells
Metabolic modulation
T cell-based immunotherapy
Exogenous metabolites
Therapeutic optimization
Online Access:https://doi.org/10.1186/s40164-024-00575-7

Internet

https://doi.org/10.1186/s40164-024-00575-7

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