The Effects of Synthetically Modified Natural Compounds on ABC Transporters

The Effects of Synthetically Modified Natural Compounds on ABC Transporters

Multidrug resistance (MDR) is a major hurdle which must be overcome to effectively treat cancer. ATP-binding cassette transporters (ABC transporters) play pivotal roles in drug absorption and disposition, and overexpression of ABC transporters has been shown to attenuate cellular/tissue drug accumul...

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Bibliographic Details
Main Authors: Daniel Dantzic, Pawan Noel, Fabrice Merien, Dong-Xu Liu, Jun Lu, Haiyong Han, Mark J. McKeage, Yan Li
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Pharmaceutics
Subjects:
ABC transporter
drug disposition
multidrug resistance
P-glycoprotein (P-gp)
breast cancer resistant protein (BCRP)
multidrug resistance-associated proteins (MRPs)
Online Access:http://www.mdpi.com/1999-4923/10/3/127

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http://www.mdpi.com/1999-4923/10/3/127

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