Synthesis of Pyridine-Dicarboxamide-Cyclohexanone Derivatives: Anticancer and α-Glucosidase Inhibitory Activities and In Silico Study

Synthesis of Pyridine-Dicarboxamide-Cyclohexanone Derivatives: Anticancer and α-Glucosidase Inhibitory Activities and In Silico Study

An efficient and practical method for the synthesis of 2,6-diaryl-4-oxo-<i>N</i>,<i>N</i>&#8242;-di(pyridin-2-yl)cyclohexane-1,1-dicarboxamide is described in this present study, which occurs through a double Michael addition reaction between diamide and various dibenzala...

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Bibliographic Details
Main Authors: Abdullah Mohammed Al-Majid, Mohammad Shahidul Islam, Saleh Atef, Fardous F. El-Senduny, Farid A. Badria, Yaseen A. M. M. Elshaier, M. Ali, Assem Barakat, A. F. M. Motiur Rahman
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Molecules
Subjects:
malonamide
Michael addition reaction
cytotoxicity
cancer
α-glucosidase
docking
Online Access:https://www.mdpi.com/1420-3049/24/7/1332

Internet

https://www.mdpi.com/1420-3049/24/7/1332

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