MicroRNA-122 supports robust innate immunity in hepatocytes by targeting the RTKs/STAT3 signaling pathway

MicroRNA-122 supports robust innate immunity in hepatocytes by targeting the RTKs/STAT3 signaling pathway

MicroRNA-122 (miR-122) is the most abundant microRNA in hepatocytes and a central player in liver biology and disease. Herein, we report a previously unknown role for miR-122 in hepatocyte intrinsic innate immunity. Restoration of miR-122 levels in hepatoma cells markedly enhanced the activation of...

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Bibliographic Details
Main Authors: Hui Xu, Shi-Jun Xu, Shu-Juan Xie, Yin Zhang, Jian-Hua Yang, Wei-Qi Zhang, Man-Ni Zheng, Hui Zhou, Liang-Hu Qu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-02-01
Series:eLife
Subjects:
miR-122
innate immunity
interferons
STAT3
IRF1
receptor tyrosine kinase
Online Access:https://elifesciences.org/articles/41159

Internet

https://elifesciences.org/articles/41159

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